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Adayabalam S Balajee Selected Research

RecQ Helicases

3/2021RNF8 ubiquitinates RecQL4 and promotes its dissociation from DNA double strand breaks.
1/2021Human RecQL4 as a Novel Molecular Target for Cancer Therapy.
9/2018RecQL4-Aurora B kinase axis is essential for cellular proliferation, cell cycle progression, and mitotic integrity.
1/2018Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells.
3/2016RECQL4 helicase has oncogenic potential in sporadic breast cancers.
1/2016Human Helicase RECQL4 Drives Cisplatin Resistance in Gastric Cancer by Activating an AKT-YB1-MDR1 Signaling Pathway.
1/2013RecQL4 helicase amplification is involved in human breast tumorigenesis.
11/2012RecQL4 cytoplasmic localization: implications in mitochondrial DNA oxidative damage repair.
11/2010Human RecQL4 helicase plays critical roles in prostate carcinogenesis.
3/2007RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability.

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Adayabalam S Balajee Research Topics

Disease

17Neoplasms (Cancer)
01/2021 - 12/2004
8Genomic Instability
03/2021 - 12/2005
6Carcinogenesis
03/2014 - 12/2009
5Breast Neoplasms (Breast Cancer)
03/2014 - 10/2011
3Rothmund-Thomson Syndrome (Syndrome, Rothmund-Thomson)
01/2021 - 11/2010
2Craniosynostosis radial aplasia syndrome
01/2021 - 09/2018
2Cockayne Syndrome (Syndrome, Cockayne)
01/2015 - 05/2008
1Ataxia Telangiectasia (Louis Bar Syndrome)
06/2022
1Chromosome Aberrations (Chromosome Abnormalities)
11/2021
1Inborn Genetic Diseases (Disease, Hereditary)
03/2021
1Werner Syndrome (Werner's Syndrome)
01/2021
1Bloom Syndrome
01/2021
1Neuroblastoma
01/2020
1Parkinson Disease (Parkinson's Disease)
01/2020
1Stomach Neoplasms (Stomach Cancer)
01/2016
1Xeroderma Pigmentosum (Kaposi's Disease)
06/2015
1Osteosarcoma (Osteogenic Sarcoma)
06/2015
1Ring Chromosomes (Ring Chromosome)
11/2014
1Ductal Carcinoma
03/2014
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
04/2013
1Lung Neoplasms (Lung Cancer)
04/2013
1Premature Aging
11/2012
1Retinoblastoma (Glioblastoma, Retinal)
11/2010
1Prostatic Neoplasms (Prostate Cancer)
11/2010
1Glioblastoma (Glioblastoma Multiforme)
02/2010
1Polyploidy
02/2010
1Brain Neoplasms (Brain Tumor)
02/2010
1Infections
01/2009
1Chromosomal Instability (Chromosome Stability)
03/2007

Drug/Important Bio-Agent (IBA)

10RecQ HelicasesIBA
03/2021 - 03/2007
8DNA (Deoxyribonucleic Acid)IBA
01/2021 - 05/2008
8Proteins (Proteins, Gene)FDA Link
01/2016 - 05/2008
3Biological ProductsIBA
01/2018 - 01/2012
21,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA
06/2022 - 11/2021
2Reactive Oxygen Species (Oxygen Radicals)IBA
01/2020 - 06/2015
2Cisplatin (Platino)FDA LinkGeneric
01/2016 - 04/2013
2Messenger RNA (mRNA)IBA
01/2016 - 01/2013
2Small Interfering RNA (siRNA)IBA
01/2013 - 11/2010
2Estrogens (Estrogen)FDA Link
02/2012 - 10/2011
2CurcuminIBA
02/2012 - 10/2011
2Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
11/2010 - 05/2008
2DNA-Activated Protein KinaseIBA
02/2010 - 05/2008
1Ubiquitin-Specific ProteasesIBA
01/2020
1mesoxalonitrileIBA
01/2020
1Deubiquitinating EnzymesIBA
01/2020
1Carbonyl Cyanide m-Chlorophenyl Hydrazone (CCCP)IBA
01/2020
1EnzymesIBA
01/2020
1NeurotoxinsIBA
01/2020
1Phosphotransferases (Kinase)IBA
01/2020
1PyrrolidinesIBA
01/2020
11- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
01/2020
1UbiquitinIBA
01/2020
1Ubiquitin-Conjugating EnzymesIBA
01/2020
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
01/2020
1Adenosine Triphosphate (ATP)IBA
06/2015
1Mitochondrial DNA (mtDNA)IBA
06/2015
1ChromatinIBA
01/2015
1RNA (Ribonucleic Acid)IBA
01/2015
1Biomarkers (Surrogate Marker)IBA
03/2014
1Hormones (Hormone)IBA
03/2014
1VimentinIBA
03/2014
1Notch ReceptorsIBA
03/2014
1Cell Adhesion MoleculesIBA
07/2013
1Poly Adenosine Diphosphate RiboseIBA
04/2013
1Checkpoint Kinase 1IBA
04/2013
1Poly(ADP-ribose) Polymerase InhibitorsIBA
04/2013
1olaparibIBA
04/2013
1veliparibIBA
04/2013
1Platinum Compounds (Compounds, Platinum)IBA
04/2013
1Drug CombinationsIBA
04/2013
1PlatinumIBA
04/2013
1Superoxides (Superoxide)IBA
11/2012
1AntioxidantsIBA
02/2012
1Proliferating Cell Nuclear Antigen (PCNA)IBA
02/2012
1IonsIBA
10/2010
1Cyclin-Dependent Kinase Inhibitor p16IBA
10/2010
1pyrimidin-2-one beta-ribofuranosideIBA
02/2010
1IsoenzymesIBA
12/2009
1Apoptosis Regulatory ProteinsIBA
12/2009
1Cyclin D1IBA
01/2009
1betaIG-H3 protein (keratoepithelin)IBA
01/2009
1Transforming Growth Factor beta (TGF-beta)IBA
01/2009
1Protein Isoforms (Isoforms)IBA
01/2008
1Protein Kinase CIBA
01/2008
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
01/2007
1LipidsIBA
01/2007
1arseniteIBA
12/2005

Therapy/Procedure

4Therapeutics
01/2021 - 02/2010
4Radiotherapy
02/2010 - 12/2004
3Drug Therapy (Chemotherapy)
04/2013 - 05/2008